DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN

PDB Details

PDB ID
2C5N
Status
CURRENT
Deposition Date
2005-10-30
Modification Date
2009-02-24
Pubmed ID
16492568
Method
X-RAY DIFFRACTION
Resolution (Å)
2.1
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 0 19
A C LBP 5 5
A N PIF 0 16
A N MPP 1 16
A N ATP 2 16
A N ATP 3 15
A N ATP 4 11
A N DFG 5 5
C C LBP 2 17
C C LBP 3 10
C C AAS 5 7
C C AAS 8 2
C N ATP 0 17
C N ATP 1 16
C N PIF 2 14
C N ATP 3 10
C N MPP 4 9
C N MT3 6 8
C N DFG 8 1

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Legend

Color Name Hit Count