Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies

PDB Details

PDB ID
2GU8
Status
CURRENT
Deposition Date
2006-04-28
Modification Date
2009-02-24
Pubmed ID
16765046
Method
X-RAY DIFFRACTION
Resolution (Å)
2.2
UniProt Accessions
P17612

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DRS 1 15
A C PMP 2 14
A C EDI 7 6
A C PMP 8 3
A N ATP 1 14
A N PIF 4 10
A N ATP 5 6
A N ATP 6 4
A N PIF 9 2

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Legend

Color Name Hit Count