IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

PDB Details

PDB ID
2VTA
Status
CURRENT
Deposition Date
2008-05-13
Modification Date
2010-10-27
Pubmed ID
18656911
Method
X-RAY DIFFRACTION
Resolution (Å)
2.0
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 0 21
A C LBP 4 8
A C EDI 6 4
A C PDIG 7 3
A C CMP 9 2
A N ATP 0 27
A N MT3 1 22
A N MT3 2 18
A N DFG 4 6
A N MPP 5 4
A N PIF 6 4

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Legend

Color Name Hit Count