IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN

PDB Details

PDB ID
2VTH
Status
CURRENT
Deposition Date
2008-05-15
Modification Date
2010-11-03
Pubmed ID
18656911
Method
X-RAY DIFFRACTION
Resolution (Å)
1.9
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 3 14
A C EDI 4 8
A C CMP 5 8
A C LBP 6 7
A C PDIG 7 2
A C PDIG 8 2
A N ATP 0 30
A N MT3 1 20
A N DFG 3 14
A N MPP 4 10
A N ATP 5 4
A N MT3 6 1

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Legend

Color Name Hit Count