IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

PDB Details

PDB ID
2VTJ
Status
CURRENT
Deposition Date
2008-05-15
Modification Date
2010-11-03
Pubmed ID
18656911
Method
X-RAY DIFFRACTION
Resolution (Å)
2.2
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 0 20
A C LBP 4 6
A C EDI 5 5
A C PDIG 7 4
A C PDIG 9 3
A N MT3 0 20
A N ATP 1 17
A N MT3 2 14
A N ATP 3 11
A N MPP 4 11
A N MT3 5 5
A N MT3 8 4

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Legend

Color Name Hit Count