IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

PDB Details

PDB ID
2VTT
Status
CURRENT
Deposition Date
2008-05-15
Modification Date
2010-11-03
Pubmed ID
18656911
Method
X-RAY DIFFRACTION
Resolution (Å)
1.68
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 0 15
A C PDIG 3 13
A C EDI 6 6
A C PDIG 7 6
A C LBP 8 5
A C LBP 9 4
A N ATP 0 27
A N MT3 1 18
A N MPP 3 8
A N MT3 4 6
A N ATP 5 5
A N MPP 7 3
A N PIF 8 2

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Legend

Color Name Hit Count