Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity

PDB Details

PDB ID
2W1H
Status
CURRENT
Deposition Date
2008-10-17
Modification Date
2012-05-16
Pubmed ID
19143567
Method
X-RAY DIFFRACTION
Resolution (Å)
2.15
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 0 18
A C EDI 4 13
A C PDIG 6 4
A C LBP 8 3
A N ATP 0 31
A N MT3 1 20
A N MT3 2 19
A N MPP 3 16
A N MT3 5 1

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Legend

Color Name Hit Count