OPTIMISATION OF 6,6-DIMETHYL PYRROLO 3,4-C PYRAZOLES: IDENTIFICATION OF PHA-793887, A POTENT CDK INHIBITOR SUITABLE FOR INTRAVENOUS DOSING

PDB Details

PDB ID
2WPA
Status
CURRENT
Deposition Date
2009-08-03
Modification Date
2010-03-23
Pubmed ID
20153204
Method
X-RAY DIFFRACTION
Resolution (Å)
2.51
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 0 20
A C CMP 3 9
A C EDI 4 9
A C PDIG 5 7
A C LBP 6 6
A N PIF 0 19
A N ATP 1 12
A N MPP 2 12
A N ATP 3 11
A N DFG 6 4
A N DFG 7 4
A N ATP 9 3
C C LBP 0 21
C C LBP 5 5
C C CMP 8 4
C C EDI 10 3
C C EDI 12 2
C N ATP 0 27
C N PIF 1 15
C N MPP 2 13
C N MT3 3 8
C N ATP 5 5
C N ATP 6 5
C N DFG 9 2

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Legend

Color Name Hit Count