Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas

PDB Details

PDB ID
2YDI
Status
CURRENT
Deposition Date
2011-03-21
Modification Date
2012-06-27
Pubmed ID
22551018
Method
X-RAY DIFFRACTION
Resolution (Å)
1.6
UniProt Accessions
O14757

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 0 16
A C PDIG 1 16
A C EDI 3 14
A C CMP 6 6
A C PDIG 8 4
A N ATP 0 26
A N MPP 2 15
A N MPP 3 12
A N MT3 4 6

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Legend

Color Name Hit Count