Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas

PDB Details

PDB ID
2YDJ
Status
CURRENT
Deposition Date
2011-03-22
Modification Date
2013-03-27
Pubmed ID
22551018
Method
X-RAY DIFFRACTION
Resolution (Å)
1.85
UniProt Accessions
O14757

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 3 11
A C PDIG 4 8
A C PDIG 5 7
A C CMP 6 6
A C EDI 8 2
A N ATP 0 22
A N MPP 2 15
A N MT3 3 12
A N MPP 4 8
B C AAS 3 13
B C EDI 4 13
B C PDIG 5 6
B C PDIG 6 4
B C CMP 8 2
B N ATP 0 25
B N MPP 1 21
B N MT3 3 15
B N MPP 5 2

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Legend

Color Name Hit Count