Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas

PDB Details

PDB ID
2YDK
Status
CURRENT
Deposition Date
2011-03-22
Modification Date
2012-06-27
Pubmed ID
22551018
Method
X-RAY DIFFRACTION
Resolution (Å)
1.9
UniProt Accessions
O14757

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C PDIG 0 22
A C CMP 3 15
A C EDI 5 7
A N ATP 0 19
A N ATP 2 13
A N MPP 3 10
A N MT3 4 9
A N MPP 5 9
A N ATP 6 4
A N MT3 7 3

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Legend

Color Name Hit Count