Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor

PDB Details

PDB ID
3EN4
Status
CURRENT
Deposition Date
2008-09-25
Modification Date
2011-07-13
Pubmed ID
18849971
Method
X-RAY DIFFRACTION
Resolution (Å)
2.55
UniProt Accessions
P00523

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 1 13
A C CMP 3 12
A C DFG 8 3
A N MPP 0 17
A N ATP 3 14
A N DFG 4 14
A N ATP 5 13
A N MPP 6 5
B C CMP 1 13
B C EDI 2 13
B C PDIG 7 6
B N ATP 0 26
B N MPP 2 15
B N DFG 4 10
B N ATP 6 4

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Legend

Color Name Hit Count