Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor

PDB Details

PDB ID
3EN5
Status
CURRENT
Deposition Date
2008-09-25
Modification Date
2011-07-13
Pubmed ID
18849971
Method
X-RAY DIFFRACTION
Resolution (Å)
2.66
UniProt Accessions
P00523

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 1 16
A C EDI 2 14
A C AAS 4 12
A C DFG 5 6
A C AAS 6 6
A C PDIG 7 5
A N PIF 0 21
A N ATP 1 20
A N ATP 3 14
A N MPP 4 13
A N MPP 5 11
B C EDI 0 14
B C CMP 1 13
B C AAS 6 8
B N MT3 0 19
B N ATP 1 18
B N MPP 2 17
B N MT3 3 12
B N ATP 5 6
B N MT3 8 3

Mapping Results Viewer

Use your mouse to drag, rotate, and zoom. Select structure to view on the right using dropdown.
Powered by NGL

Legend

Color Name Hit Count