Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP102, a multitargeted kinase inhibitor

PDB Details

PDB ID
3EN6
Status
CURRENT
Deposition Date
2008-09-25
Modification Date
2011-07-13
Pubmed ID
18849971
Method
X-RAY DIFFRACTION
Resolution (Å)
2.39
UniProt Accessions
P00523

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 2 16
A C CMP 4 12
A C DFG 5 7
A N MT3 1 17
A N MPP 2 16
A N MPP 3 15
A N ATP 4 12
A N MPP 7 2
B C AAS 0 18
B C DRS 1 13
B C CMP 5 10
B C EDI 7 7
B C AAS 9 2
B N ATP 0 27
B N MPP 1 17
B N MPP 3 16
B N DFG 4 10
B N ATP 6 2

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Legend

Color Name Hit Count