Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor

PDB Details

PDB ID
3EN7
Status
CURRENT
Deposition Date
2008-09-25
Modification Date
2011-07-13
Pubmed ID
18849971
Method
X-RAY DIFFRACTION
Resolution (Å)
2.81
UniProt Accessions
P00523

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 0 14
A C AAS 2 11
A C CMP 5 10
A C PDIG 9 5
A N ATP 0 26
A N MPP 2 16
A N MT3 4 11
B C CMP 0 16
B C EDI 2 14
B C AAS 6 6
B N MPP 0 20
B N MPP 1 18
B N MT3 2 16
B N ATP 4 11
B N MT3 6 7

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Legend

Color Name Hit Count