AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

PDB Details

PDB ID
3IK3
Status
CURRENT
Deposition Date
2009-08-05
Modification Date
2010-04-28
Pubmed ID
19878872
Method
X-RAY DIFFRACTION
Resolution (Å)
1.9
UniProt Accessions
P00520

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 0 19
A C AAS 3 9
A C DFG 4 9
A C DRS 5 8
A C DFG 6 7
A C AAS 7 4
A N MPP 0 19
A N ATP 2 17
A N ATP 3 16
A N MPP 4 9
B C AAS 0 27
B C PDIG 3 8
B C DRS 4 7
B C DFG 7 5
B C ATP 9 4
B C AAS 10 3
B N MPP 0 24
B N ATP 1 16
B N ATP 3 12
B N DFG 9 2
B N MPP 10 2

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Legend

Color Name Hit Count