Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

PDB Details

PDB ID
3JXW
Status
CURRENT
Deposition Date
2009-09-21
Modification Date
2009-11-10
Method
X-RAY DIFFRACTION
Resolution (Å)
2.8
UniProt Accessions
P11309

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 0 19
A C PDIG 6 5
A C PDIG 7 4
A C CMP 10 2
A N MT3 0 17
A N DFG 3 12
A N ATP 4 12
A N ATP 6 7
A N MT3 8 3

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Legend

Color Name Hit Count