Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

PDB Details

PDB ID
3JYA
Status
CURRENT
Deposition Date
2009-09-21
Modification Date
2009-11-10
Method
X-RAY DIFFRACTION
Resolution (Å)
2.1
UniProt Accessions
P11309

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 1 15
A C PDIG 7 4
A C LBP 8 4
A C CMP 9 3
A N ATP 0 25
A N ATP 2 14
A N DFG 4 9
A N MT3 5 8
A N ATP 7 1

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Legend

Color Name Hit Count