Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

PDB Details

PDB ID
3KF4
Status
CURRENT
Deposition Date
2009-10-27
Modification Date
2010-09-01
Pubmed ID
19895503
Method
X-RAY DIFFRACTION
Resolution (Å)
1.9
UniProt Accessions
P00520

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DRS 5 8
A C CMP 6 6
A C AAS 7 5
A N ATP 1 18
A N ATP 2 14
A N MPP 3 12
A N ATP 5 5
A N MPP 9 2
A N DFG 10 2
B C DEF 1 13
B C CMP 4 8
B C DRS 5 8
B C PDIG 9 5
B N MPP 0 19
B N ATP 2 13
B N ATP 3 12
B N MPP 4 10
B N ATP 5 5
B N DFG 6 5
B N ATP 9 3
B N MPP 10 3

Mapping Results Viewer

Use your mouse to drag, rotate, and zoom. Select structure to view on the right using dropdown.

Legend

Color Name Hit Count