Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

PDB Details

PDB ID
3KFA
Status
CURRENT
Deposition Date
2009-10-27
Modification Date
2010-09-01
Pubmed ID
19895503
Method
X-RAY DIFFRACTION
Resolution (Å)
1.22
UniProt Accessions
P00520

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 2 10
A C AAS 4 9
A C DFG 7 4
A C DRS 9 2
A C AAS 12 2
A N ATP 0 17
A N MPP 1 17
A N ATP 2 15
A N MPP 3 12
A N ATP 7 4
A N MPP 9 3
B C DRS 7 5
B C DFG 8 4
B C AAS 11 2
B N MPP 0 20
B N ATP 2 19
B N ATP 3 11
B N ATP 6 5

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Legend

Color Name Hit Count