Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

PDB Details

PDB ID
3PYY
Status
CURRENT
Deposition Date
2010-12-13
Modification Date
2011-03-09
Pubmed ID
21338916
Method
X-RAY DIFFRACTION
Resolution (Å)
1.85
UniProt Accessions
P00519

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 0 23
A C CMP 2 11
A C CMP 5 6
A C DFG 7 5
A C AAS 9 3
A C DRS 11 2
A C AAS 12 2
A N MPP 0 23
A N ATP 1 22
A N ATP 2 19
A N DFG 5 5
B C AAS 1 15
B C CMP 2 15
B C DRS 3 13
B C CMP 5 7
B C DFG 6 6
B C PDIG 9 2
B N MPP 0 23
B N DFG 1 21
B N ATP 3 18
B N MPP 4 6
B N MPP 5 3

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Legend

Color Name Hit Count