Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series

PDB Details

PDB ID
3SHE
Status
CURRENT
Deposition Date
2011-06-16
Modification Date
2012-01-11
Pubmed ID
22119462
Method
X-RAY DIFFRACTION
Resolution (Å)
2.25
UniProt Accessions
Q16644

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DRS 1 14
A C DRS 2 13
A C DRS 4 10
A C DRS 5 6
A C DRS 6 5
A C AAS 7 5
A N DFG 3 12
A N ATP 5 7
A N ATP 6 5
A N DFG 7 5
A N ATP 8 4

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Legend

Color Name Hit Count