Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain

PDB Details

PDB ID
3UE4
Status
CURRENT
Deposition Date
2011-10-28
Modification Date
2012-04-25
Pubmed ID
22493660
Method
X-RAY DIFFRACTION
Resolution (Å)
2.42
UniProt Accessions
P00519

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 7 6
A C DRS 8 4
A C AAS 9 4
A C CMP 10 2
A C CMP 12 2
A N MT3 0 20
A N MPP 2 16
A N DFG 3 13
A N MPP 4 13
A N ATP 5 10
A N MT3 7 3
B C DRS 5 9
B C CMP 6 4
B C CMP 7 3
B C LBP 8 3
B N MPP 2 13
B N ATP 3 12
B N DFG 4 7
B N ATP 5 6
B N MPP 6 4
B N MT3 7 4

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Legend

Color Name Hit Count