Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity

PDB Details

PDB ID
3VAP
Status
CURRENT
Deposition Date
2011-12-29
Modification Date
2012-05-23
Pubmed ID
22503250
Method
X-RAY DIFFRACTION
Resolution (Å)
2.66
UniProt Accessions
O14965

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 1 15
A C PDIG 2 12
A C EDI 7 4
A C AAS 9 2
A N MPP 0 21
A N MT3 1 19
A N ATP 3 14
A N MT3 5 11

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Legend

Color Name Hit Count