Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases

PDB Details

PDB ID
4AGW
Status
CURRENT
Deposition Date
2012-02-01
Modification Date
2012-02-15
Pubmed ID
20299508
Method
X-RAY DIFFRACTION
Resolution (Å)
2.6
UniProt Accessions
P00523

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DRS 0 18
A C DFG 1 16
A C EDI 2 14
A C DRS 3 12
A C LBP 7 3
A C AAS 8 2
A N ATP 1 16
A N DFG 2 15
A N MPP 3 12
A N ATP 4 10
A N ATP 5 9
B C DRS 0 18
B C EDI 1 15
B C DFG 2 14
B C DRS 4 11
B C AAS 8 2
B C LBP 9 2
B N ATP 0 16
B N DFG 1 15
B N MPP 2 15
B N ATP 5 12
B N ATP 6 7

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Legend

Color Name Hit Count