Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.

PDB Details

PDB ID
4AN2
Status
CURRENT
Deposition Date
2012-03-14
Modification Date
2014-06-18
Pubmed ID
24900486
Method
X-RAY DIFFRACTION
Resolution (Å)
2.5
UniProt Accessions
Q02750

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C MT3 0 24
A C AAS 1 19
A C DRS 6 4
A N MT3 3 16
A N ATP 6 4
A N MT3 9 3

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Legend

Color Name Hit Count