Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.

PDB Details

PDB ID
4AN9
Status
CURRENT
Deposition Date
2012-03-16
Modification Date
2014-06-18
Pubmed ID
24900486
Method
X-RAY DIFFRACTION
Resolution (Å)
2.8
UniProt Accessions
Q02750

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C MT3 0 22
A C AAS 3 12
A C DRS 4 8
A C PDIG 8 2
A N MT3 0 21
A N ATP 8 2

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Legend

Color Name Hit Count