Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule

PDB Details

PDB ID
4AU8
Status
CURRENT
Deposition Date
2012-05-14
Modification Date
2013-03-27
Pubmed ID
22889803
Method
X-RAY DIFFRACTION
Resolution (Å)
1.9
UniProt Accessions
Q00535

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 0 16
A C PDIG 1 15
A C EDI 7 6
A N ATP 0 28
A N MPP 1 14
A N DFG 3 12
A N MT3 5 6
A N ATP 6 5
A N ATP 7 3

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Legend

Color Name Hit Count