Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Details

PDB ID
4CFM
Status
CURRENT
Deposition Date
2013-11-18
Modification Date
2014-12-10
Pubmed ID
24304238
Method
X-RAY DIFFRACTION
Resolution (Å)
2.85
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 2 15
A C LBP 3 14
A C LBP 4 12
A C EDI 7 3
A C PDIG 10 2
A N ATP 0 26
A N PIF 1 18
A N MPP 2 15
A N ATP 5 6
A N ATP 6 4
A N DFG 7 3
A N ATP 8 2

Mapping Results Viewer

Use your mouse to drag, rotate, and zoom. Select structure to view on the right using dropdown.
Powered by NGL

Legend

Color Name Hit Count