Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Details

PDB ID
4CFN
Status
CURRENT
Deposition Date
2013-11-19
Modification Date
2014-02-12
Pubmed ID
24304238
Method
X-RAY DIFFRACTION
Resolution (Å)
2.2
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 2 11
A C CMP 6 7
A C LBP 7 6
A C LBP 8 5
A C EDI 9 4
A N ATP 0 27
A N PIF 2 17
A N MPP 3 13
A N DFG 4 10

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Legend

Color Name Hit Count