Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Details

PDB ID
4CFV
Status
CURRENT
Deposition Date
2013-11-19
Modification Date
2014-12-10
Pubmed ID
24304238
Method
X-RAY DIFFRACTION
Resolution (Å)
2.0
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 0 16
A C CMP 1 16
A C LBP 3 12
A C CMP 6 7
A N ATP 0 27
A N PIF 1 19
A N MPP 2 15
A N DFG 3 8
A N ATP 4 6
A N DFG 5 5

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Legend

Color Name Hit Count