Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Details

PDB ID
4CFW
Status
CURRENT
Deposition Date
2013-11-19
Modification Date
2014-02-12
Pubmed ID
24304238
Method
X-RAY DIFFRACTION
Resolution (Å)
2.45
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 1 16
A C CMP 4 10
A C LBP 6 6
A C EDI 8 4
A N ATP 0 29
A N PIF 1 21
A N MPP 2 14
A N DFG 4 7
A N ATP 5 6
A N ATP 6 3

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Legend

Color Name Hit Count