Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Details

PDB ID
4CFX
Status
CURRENT
Deposition Date
2013-11-19
Modification Date
2014-12-10
Pubmed ID
24304238
Method
X-RAY DIFFRACTION
Resolution (Å)
3.5
UniProt Accessions
P24941

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 0 17
A C LBP 2 12
A C LBP 5 8
A C LBP 7 5
A C EDI 9 4
A C LBP 10 3
A N ATP 0 29
A N PIF 1 18
A N MPP 2 17
A N DFG 3 11
A N ATP 5 3

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Legend

Color Name Hit Count