Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

PDB Details

PDB ID
4CLJ
Status
CURRENT
Deposition Date
2014-01-14
Modification Date
2014-09-17
Pubmed ID
24819116
Method
X-RAY DIFFRACTION
Resolution (Å)
1.66
UniProt Accessions
Q9UM73

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 2 13
A N PIF 0 17
A N ATP 5 9
A N DFG 6 9
A N ATP 7 4

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Legend

Color Name Hit Count