Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

PDB Details

PDB ID
4F08
Status
CURRENT
Deposition Date
2012-05-03
Modification Date
2013-05-29
Pubmed ID
22698084
Method
X-RAY DIFFRACTION
Resolution (Å)
2.82
UniProt Accessions
O60674

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A N MT3 1 16
A N ATP 2 16
A N PIF 7 2
B C DEF 0 18
B N MT3 2 16
B N ATP 4 14

Mapping Results Viewer

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Legend

Color Name Hit Count