Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations

PDB Details

PDB ID
4QQ5
Status
CURRENT
Deposition Date
2014-06-26
Modification Date
2015-01-28
Pubmed ID
25317566
Method
X-RAY DIFFRACTION
Resolution (Å)
2.2
UniProt Accessions
P22455

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DEF 2 15
A C DFG 5 6
A C EDI 6 6
A N MPP 1 18
A N ATP 5 7
A N MT3 6 6
A N ATP 7 3

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Legend

Color Name Hit Count