Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations

PDB Details

PDB ID
4R6V
Status
CURRENT
Deposition Date
2014-08-26
Modification Date
2014-11-26
Pubmed ID
25349422
Method
X-RAY DIFFRACTION
Resolution (Å)
2.35
UniProt Accessions
P22455

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 4 10
A C DFG 5 9
A N MPP 0 19
A N ATP 5 7
A N MT3 6 7
A N DFG 7 6
A N ATP 9 4

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Legend

Color Name Hit Count