Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

PDB Details

PDB ID
4TW9
Status
CURRENT
Deposition Date
2014-06-30
Modification Date
2014-10-22
Pubmed ID
25191940
Method
X-RAY DIFFRACTION
Resolution (Å)
2.4
UniProt Accessions
P48730

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C LBP 4 11
A C DRS 5 10
A C DRS 6 3
A N ATP 0 28
A N DFG 1 15
A N ATP 4 10
A N MT3 8 2

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Legend

Color Name Hit Count