(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB Details

PDB ID
4YNE
Status
CURRENT
Deposition Date
2015-03-09
Modification Date
2015-06-03
Pubmed ID
26005534
Method
X-RAY DIFFRACTION
Resolution (Å)
2.02
UniProt Accessions
P04629

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C AAS 2 16
A C DFG 5 5
A C DRS 6 5
A N MPP 0 18
A N ATP 2 16
A N PIF 5 8
A N MT3 7 3

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Legend

Color Name Hit Count