(R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors

PDB Details

PDB ID
4YPS
Status
CURRENT
Deposition Date
2015-03-13
Modification Date
2015-06-03
Pubmed ID
26005534
Method
X-RAY DIFFRACTION
Resolution (Å)
2.1
UniProt Accessions
P04629

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C DEF 3 11
A C DFG 7 5
A C DFG 9 3
A N ATP 2 14
A N PIF 4 12
A N MPP 5 10
A N MT3 8 2

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Legend

Color Name Hit Count