Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide

PDB Details

PDB ID
4Z16
Status
CURRENT
Deposition Date
2015-03-26
Modification Date
2016-02-10
Pubmed ID
26258521
Method
X-RAY DIFFRACTION
Resolution (Å)
2.9
UniProt Accessions
P52333

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C PDIG 3 12
A C AAS 4 8
A C PDIG 5 7
A C CMP 7 5
A N PIF 0 21
A N MPP 3 10
A N ATP 5 8
A N DFG 6 7
A N DFG 8 5

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Legend

Color Name Hit Count