Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

PDB Details

PDB ID
5AA8
Status
CURRENT
Deposition Date
2015-07-23
Modification Date
2016-06-08
Pubmed ID
26698910
Method
X-RAY DIFFRACTION
Resolution (Å)
1.86
UniProt Accessions
Q9UM73

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 7 8
A N PIF 0 20
A N ATP 5 9
A N DFG 7 4

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Legend

Color Name Hit Count