Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

PDB Details

PDB ID
5AA9
Status
CURRENT
Deposition Date
2015-07-23
Modification Date
2016-06-08
Pubmed ID
26698910
Method
X-RAY DIFFRACTION
Resolution (Å)
1.93
UniProt Accessions
Q9UM73

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C CMP 8 5
A N PIF 0 18
A N ATP 5 8
A N MT3 7 3
A N DFG 8 3

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Legend

Color Name Hit Count