Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

PDB Details

PDB ID
5DWR
Status
CURRENT
Deposition Date
2015-09-22
Modification Date
2015-11-25
Pubmed ID
26505898
Method
X-RAY DIFFRACTION
Resolution (Å)
2.0
UniProt Accessions
P11309

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 1 17
A C PDIG 2 15
A C DRS 3 10
A C CMP 4 8
A C DRS 6 6
A C LBP 7 4
A C PDIG 8 4
A N ATP 1 17
A N DFG 3 15
A N ATP 5 5
A N DFG 6 4

Mapping Results Viewer

Use your mouse to drag, rotate, and zoom. Select structure to view on the right using dropdown.
Powered by NGL

Legend

Color Name Hit Count