Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide

PDB Details

PDB ID
5HD7
Status
CURRENT
Deposition Date
2016-01-04
Modification Date
2016-06-01
Pubmed ID
26832798
Method
X-RAY DIFFRACTION
Resolution (Å)
1.69
UniProt Accessions
P63086

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 0 16
A C EDI 4 9
A C DRS 10 2
A N MT3 0 16
A N PIF 1 14
A N PIF 2 13
A N ATP 4 11
A N MT3 8 3
A N ATP 9 3

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Legend

Color Name Hit Count