Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers

PDB Details

PDB ID
5KE0
Status
CURRENT
Deposition Date
2016-06-09
Modification Date
2016-07-27
Pubmed ID
27329786
Method
X-RAY DIFFRACTION
Resolution (Å)
1.68
UniProt Accessions
P63086

Mapping Results

Chain Terminus Site Consensus Site Rank Consensus Site Population
A C EDI 2 14
A C EDI 5 7
A C LBP 7 5
A C LBP 8 5
A C DRS 10 2
A N PIF 0 17
A N ATP 4 10
A N PIF 5 10
A N PIF 7 3
A N MT3 10 2

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Legend

Color Name Hit Count