- Protein Name
- Bone morphogenetic protein receptor type-1B
- Gene Name
- BMPR1B
- Organism
-
Homo sapiens
- Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
15 |
2 |
3.0 |
| EDI |
9 |
9 |
9.0 |
| MT3 |
8 |
2 |
4.0 |
| AAS |
3 |
3 |
3.0 |
| ATP |
17 |
1 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
AFO00238
|
0 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3MDY
|
0 |
3 |
0 |
0 |
0 |
9 |
8 |
3 |
0 |
0 |
0 |
17 |
0 |