O00444

Background

Protein Name
Serine/threonine-protein kinase PLK4
Gene Name
PLK4
Organism
Homo sapiens

Annotations

Function
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 29 5 26.0
DFG 25 7 16.0
PIF 23 12 16.0
EDI 7 7 7.0
MT3 15 3 9.5
AAS 18 4 11.5
CMP 16 7 15.0
ATP 27 9 18.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 3 1 1 0 0 0 0 1 0 1 0 3 0
4JXF 26 0 0 0 0 0 15 12 0 15 0 27 0
3COK 29 7 23 0 0 0 10 12 0 15 0 18 0
AFO00444 0 25 0 0 0 0 0 0 0 16 0 0 0
4YUR 17 0 12 0 0 7 11 18 0 7 0 18 0