O14733

Background

Protein Name
Dual specificity mitogen-activated protein kinase kinase 7
Gene Name
MAP2K7
Organism
Homo sapiens

Annotations

Function
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MT3 13 4 12.0
PIF 5 5 5.0
ATP 19 5 16.0
DRS 22 2 17.0
AAS 25 4 11.0
MPP 15 9 12.0
LBP 15 3 9.0
CMP 15 2 8.0
PDIG 5 3 4.0

Mapping Results

PDB ID Maximum Consensus Site Population
EDI site MT3 site PIF site ATP site DEF site DRS site AAS site MPP site DFG site LBP site CMP site PDIG site PMP site
Total Druggable Structures per Site 0 0 0 3 0 4 2 0 0 0 0 0 0
3WZU 0 13 5 5 0 22 11 0 0 0 15 3 0
5B2M 0 12 0 13 0 20 11 0 0 0 13 0 0
5B2L 0 0 0 19 0 12 9 9 0 3 2 0 0
5B2K 0 4 0 19 0 17 16 0 0 15 6 5 0
2DYL 0 0 0 16 0 20 25 15 0 0 8 0 0