- Protein Name
- Peripheral plasma membrane protein CASK
- Gene Name
- CASK
- Organism
-
Homo sapiens
- Function
- Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
5 |
2 |
3.0 |
| DFG |
16 |
9 |
14.5 |
| PIF |
16 |
2 |
11.0 |
| DRS |
17 |
1 |
10.0 |
| EDI |
16 |
9 |
14.5 |
| MT3 |
17 |
3 |
9.0 |
| PDIG |
21 |
3 |
12.0 |
| ATP |
25 |
5 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
1 |
2 |
0 |
3 |
1 |
0 |
0 |
0 |
1 |
5 |
0 |
|
3MFT
|
5 |
0 |
16 |
10 |
0 |
14 |
14 |
0 |
0 |
0 |
0 |
13 |
0 |
|
3C0H
|
3 |
15 |
15 |
14 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
22 |
0 |
|
3MFR
|
3 |
0 |
11 |
3 |
0 |
16 |
17 |
0 |
0 |
0 |
0 |
14 |
0 |
|
3MFU
|
3 |
13 |
7 |
15 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
|
3MFS
|
2 |
15 |
15 |
6 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
|
AFO14936
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3C0I
|
5 |
14 |
10 |
17 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
|
3TAC
|
0 |
9 |
15 |
16 |
0 |
13 |
3 |
0 |
0 |
0 |
21 |
14 |
0 |
|
3C0G
|
0 |
16 |
14 |
14 |
0 |
11 |
4 |
0 |
0 |
0 |
0 |
25 |
0 |